LOSE WEIGHT, LOWER BMI SMALLER WAIST HEALTHY JOINTS
PRO STRENGTH WEIGHT LOSS
FASTER RECOVERY
PRO JOINT & BONE HEALTH
POWERFUL ANT-OXIDANT
The purpose of the present study was to investigate the use of a Cissus quadrangularis formulation in the management of metabolic syndrome, particularly weight loss and central obesity.The study was a randomized, double-blind, placebo-controlled design involving 123 overweight and obese persons (47.2% male; 52.8% female; ages 19–50). The 92 obese (BMI >30) participants were randomized into three groups; placebo, formulation/no diet, and formulation/diet (2100–2200 calories/day). The 31 overweight participants (BMI = 25–29) formed a fourth (no diet) treatment group. All participants received two daily doses of the formulation or placebo and remained on a normal or calorie-controlled diet for 8 weeks.
Results
At the end of the trial period, statistically significant net reductions in weight and central obesity, as well as in fasting blood glucose, total cholesterol, LDL-cholesterol, triglycerides, and C-reactive protein were observed in participants who received the formulation, regardless of diet.
Although still defined in diverse terms, metabolic syndrome is a common disorder arising as a result of the increased prevalence of obesity throughout the world . Metabolic syndrome, also known as insulin resistance syndrome and Syndrome X, has 3 main potential etiologic categories: obesity and disorders of adipose tissue; insulin resistance; and a constellation of independent factors (e.g., molecules of hepatic, vascular, and immunologic origin) that mediate specific components of the metabolic syndrome.
In the United States, over 60% of the adult population is now overweight or obese and 47 million people have metabolic syndrome, which will soon overtake cigarette smoking as the number one risk factor for heart disease . Globally, the disorder has become a major public health challenge.
Obesity has been shown to contribute to high serum cholesterol, low HDL cholesterol and hyperglycemia, all of which increase the chances of cardiovascular disease (CVD) . Correlations between central obesity and high blood pressure, high blood cholesterol, low levels of high density lipoprotein-cholesterol, and high fasting blood glucose levels have been shown for both sexes in various racial and ethnic groups .
Since it has been determined that abdominal fat poses a greater health risk than fat stored in the lower half of the body, waist circumference has become a major factor in body-fat assessment . A large waist circumference (>88 cm in women and 102 cm in men) is associated with an increased risk for type 2 diabetes, dyslipidemia, hypertension and CVD in patients with a body mass index (BMI) 25–34 . Moreover, for obese patients with metabolic complications, changes in waist circumference are useful predictors of CVD risk factors . Thus, in addition to weight (kg), fat (%) and BMI, changes in waist measurement (cm) was one of the primary endpoints in this study ~ The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome by Julius Oben, Dieudonne Kuate, Gabriel Agbor1, Claudia Momo and Xavio Talla Department of Biochemistry, University of Yaoundé I, Yaoundé, Cameroon.
Cissus quadrangularis was prescribed in the ancient Ayurvedic texts as a general tonic. Modern research has shed light on Cissus' ability to help support bone health by showing it acts as a glucocorticoid antagonist . Since anabolic/androgenic compounds are well known to act as antagonists to the glucocorticoid receptor as well as promote good bone health, it has been postulated that Cissus possesses anabolic and/or androgenic properties .
Cissus quadrangularis contains high amount of vitamin C, carotene A, anabolic steroidal substances and calcium. These anabolic steroidal principles from Cissus quadrangularis showed a marked influence in the rate of fracture-healing by influencing early regeneration of all connective tissues of mesenchyma origin, namely the fibroblasts, the chondroblasts and osteoblasts involved in the healing and quicker mineralization of the callus. It has greater impact on osteoblastic proliferation than other cellular responses.
Cissus quadrangularis causes less amount of tissue reaction in the fractured region leading to optimum decalcification in the early stage with minimum of callus formation. Hence deposition of calcium is just enough to join the two broken segments of bone so that it’s remodeling takes much faster. This early completion of calcification process and earlier remodeling phenomenon lead to early recovery of Cissus treated animals. Cissus is also shown to cause early gain in the tensile strength of fractured bones of about 90 per cent of its normal strength at the end of 6 week. Cissus quadrangularis builds up the chemical composition of the fractured bone namely its mucopolysaccharides, collagen, calcium, phosphorus and others as well as its functional efficiency. Mucopolysaccharides play an important role in the healing by supplying raw materials for repairs. Therefore it seems that in the early period of bone fracture healing the greater the accumulation of these materials more rapid will be the rate of healing. Rapid the utilization of these raw materials earlier will be completion of healing process. Cissus quadrangualris not only causes the greater accumulation of mucopolysaccharides but also an earlier disappearance of mucopolysaccharides from the fractured area, associated with the earlier calcification and firmer callus formation.
In clinical trials Cissus quadrangularis as per radiological and clinical observations has been found to cause considerable reduction in the healing time of fractures by 55-33 percent.
Supplement Facts
Serving Size: 2 Capsules
Servings Per Container: 60
Amount Per Serving
Cissus Quadrangularis Extract 1000MG +
(Standardized for 20% 3-Ketosterone)
+ Daily Value not established
* Percent Daily Values are based on 2,000 calorie diet.
Other Ingredients:
Magnesium Stearate, Gelatin
Suggested Use:
As a dietary supplement, take 2 capsules 30 minutes prior to a meal in the morning and 2 capsules 30 minutes prior to meal 6-8 hours later in the day.
Free of: yeast, wheat, gluten, corn, soy, milk, sugar, sat, colors and preservatives. Contains NO solvent residues.
120 Capsules
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